GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| THCA | cis | rs7116495 | 1 | rs6592448 | chr11:71670044 | FAM86C | chr11:71498557-71512276:+ | -0.33 | -4.04 | 6.34E-5 | Severe influenza A (H1N1) infection |
| THCA | cis | rs7116495 | 1 | rs6592450 | chr11:71671166 | FAM86C | chr11:71498557-71512276:+ | 0.31 | 4.01 | 7.05E-5 | Severe influenza A (H1N1) infection |
| THCA | cis | rs7116495 | 1 | rs6592453 | chr11:71683231 | FAM86C | chr11:71498557-71512276:+ | 0.32 | 3.89 | 0.000116 | Severe influenza A (H1N1) infection |
| THCA | cis | rs7116495 | 1 | rs6592455 | chr11:71689541 | FAM86C | chr11:71498557-71512276:+ | -0.37 | -4.54 | 7.13E-6 | Severe influenza A (H1N1) infection |
| THCA | cis | rs7107174 | 1 | rs6592772 | chr11:78015563 | NARS2 | chr11:78147017-78285909:- | -0.36 | -6.48 | 2.25E-10 | Testicular germ cell tumor |
| THCA | cis | rs709400 | 1 | rs6593 | chr14:104163282 | KLC1 | chr14:104029299-104167887:+ | -0.21 | -4.11 | 4.7E-5 | Body mass index |
| THCA | cis | rs7552404 | 1 | rs6593585 | chr1:76140273 | MSH4 | chr1:76262630-76378923:+ | 0.25 | 4.19 | 3.29E-5 | Blood metabolite levels;Acylcarnitine levels |
| THCA | cis | rs3853750 | 1 | rs6594480 | chr5:110173859 | TMEM232 | chr5:109624934-110062381:- | 0.2 | 3.88 | 0.000119 | Asthma and hay fever |
| THCA | cis | rs13174348 | 1 | rs6594906 | chr5:115171435 | ATG12 | chr5:115165818-115177520:- | 0.27 | 5.63 | 3.05E-8 | IgG glycosylation |
| THCA | cis | rs13174348 | 1 | rs6594906 | chr5:115171435 | CCDC112 | chr5:114602885-114632458:- | 0.18 | 3.61 | 0.000342 | IgG glycosylation |
| THCA | cis | rs13174348 | 1 | rs6594906 | chr5:115171435 | CDO1 | chr5:115140432-115152405:- | 0.37 | 7.28 | 1.42E-12 | IgG glycosylation |
| THCA | cis | rs7116495 | 1 | rs659513 | chr11:71812411 | FAM86C | chr11:71498557-71512276:+ | -0.33 | -3.94 | 9.21E-5 | Severe influenza A (H1N1) infection |
| THCA | cis | rs6878284 | 1 | rs6596482 | chr5:101736641 | SLCO4C1 | chr5:101569694-101632253:- | 0.24 | 5.54 | 5.12E-8 | Schizophrenia |
| THCA | cis | rs6878284 | 1 | rs6596484 | chr5:101750196 | SLCO4C1 | chr5:101569694-101632253:- | 0.24 | 5.61 | 3.48E-8 | Schizophrenia |
| THCA | cis | rs6878284 | 1 | rs6596490 | chr5:101768045 | SLCO4C1 | chr5:101569694-101632253:- | 0.24 | 5.54 | 5.1E-8 | Schizophrenia |